Amidrazones and derivatives thereof

Details Amidrazones and derivatives thereof Amidrazones and derivatives thereof

1991-05-07

1992-07-14

Cintins, Marianne

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

424 54, A61K 31155, A61K 722

Patent

active

051303370

ABSTRACT:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) which contain novel amidrazones and derivatives thereof. Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

REFERENCES:
patent: 4456769 (1984-06-01), Bonse et al.
Brownlee et al. Science 232 1629-1632 1986.

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