Amidrazones and derivatives thereof

Details Amidrazones and derivatives thereof Amidrazones and derivatives thereof

1992-05-28

1993-11-16

Mars, Howard T.

Drug, bio-affecting and body treating compositions

Dentifrices

Ammonia, amine, or derivative thereof

514632, A61K 3155, A61K 722

Patent

active

052621529

ABSTRACT:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) which contain novel amidrazones and derivatives thereof. Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

REFERENCES:
patent: 4758583 (1988-07-01), Cerami et al.
patent: 4978684 (1990-12-01), Cerami et al.
patent: 5100919 (1992-03-01), Ulrich et al.
patent: 5106877 (1992-04-01), Ulrich et al.
patent: 5114943 (1992-05-01), Ulrich et al.
patent: 5128360 (1992-07-01), Cerami et al.
Brownlee et al., Science, 232, 1629-1632, 1986.

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