Amido-phenyl-.alpha.-D-glucopyranoside derivatives

Details Amido-phenyl-.alpha.-D-glucopyranoside derivatives Amido-phenyl-.alpha.-D-glucopyranoside derivatives

1983-11-02

1985-08-20

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 772, C07H 1518

Patent

active

045365725

ABSTRACT:
Synthesized succinyl and glutaryl glucosamines, p-(succinylamido)-phenyl-.alpha.-D-gluco- and mannopyranosides, p-(glutarylamido)-phenyl-.alpha.-D-gluco- and mannopyranosides and p-(isothiocyanotophenyl)-.alpha.-D-gluco- and mannopyranosides are reacted with insulin to form corresponding glycosylated insulins containing from 1 to 3 glycosyl groups per insulin molecule. The novel glycosylated insulins resist aggregation and show significant activity in depressing blood sugar levels.

REFERENCES:
patent: 4401661 (1983-08-01), Schaub et al.

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