(Amido)N-substituted bleomycins, salts thereof and process for p

Details (Amido)N-substituted bleomycins, salts thereof and process for p (Amido)N-substituted bleomycins, salts thereof and process for p

1982-12-20

1984-09-18

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

044723040

ABSTRACT:
A promising carcinostatic (amido)N-substituted bleomycin represented by the following formula, or a salt thereof and a process for the preparation thereof: ##STR1## wherein BM represents a moiety of bleomycin skeleton; X represents an alkyl of 1 to 18 carbon atoms, an aminoalkyl of 1 to 12 carbon atoms, a lower alkyl having a halogen, phenyl indolyl, 5- or 6-membered heterocyclic group, or (lower)alkylamino (the alkyl group may have a substituent group) as a substituent, naphthyl, thiazolyl, or N-phenyl(lower)alkylpiperazinyl; and R represents a terminal amino residue of the bleomycin.

REFERENCES:
patent: Re30413 (1980-10-01), Umezawa et al.
patent: Re30451 (1980-12-01), Umezawa et al.
patent: 3846400 (1974-11-01), Umezawa et al.
patent: 3932374 (1976-01-01), Umezawa et al.
patent: 4267102 (1981-05-01), Fujii et al.
patent: 4315851 (1982-02-01), Yoshikumi et al.
patent: 4326054 (1982-04-01), Umezawa et al.
patent: 4339426 (1982-07-01), Meares et al.

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