Amido derivatives of 2,4,6-triiodobenzoic acids containing at le

Details Amido derivatives of 2,4,6-triiodobenzoic acids containing at le Amido derivatives of 2,4,6-triiodobenzoic acids containing at le

1974-12-02

1977-05-03

Wyman, Daniel E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260490, 260559A, 424 5, 536 22, C07C10326, A61K 2902

Patent

active

040214818

ABSTRACT:
This invention relates to novel X-ray contrast agents particularly for use in the cerebrospinal cavities, comprising non-ionic alkanols carrying at least one N-bonded secondary or tertiary amide group and having at least two hydroxyl groups and at least one iodine atom in the molecule. Particularly useful compounds include the N-hydroxyalkyl iodoalkane sulphonamides having at least two hydroxyl groups, tri- and tetra-iodobenzene carrying carbamoyl, acylamino and/or acylaminomethyl substituents and having at least two hydroxyl groups in the molecule and at least one N-hydroxyalkyl group. Particularly preferred compounds comprise 2,4,6-triiodobenzamides which may be 3- and/or 5-substituted with a variety of groups. The compounds all show markedly low toxicities and a number show very high levels of water solubility.

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