Amidinophenylalanine derivatives, process for their preparation,

Details Amidinophenylalanine derivatives, process for their preparation, Amidinophenylalanine derivatives, process for their preparation,

1992-04-07

1993-12-28

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546196, 546205, 540200, 540483, 540607, 548540, 564 81, C07D21106, C07D40510

Patent

active

052740986

ABSTRACT:
Amidinophenylalanine derivatives, a process for their preparation, their use and pharmaceutical compositions which contain these compounds are described.

REFERENCES:
patent: 4028380 (1977-06-01), Panneman et al.
Selective Inhibition of Thrombin by (2R,4R)-4-Methyl-1-[N.sup.2 -[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl(]-2-piperi dinecarboxylic Acid by R. Kikumoto et al., Biochemistry (1984) vol. 23, pp. 85-90.
Comparison of the Anticoagulant and Antithrombotic Effects of Synthetic Thrombin and Factor Xa Inhibitors by J. Hauptmann et al., Thrombosis and Haemostasis 63(2):220-223 (1990).
Pharmacological Characterization of a New Highly Effective Synthetic Thrombin Inhibitor by B. Kaiser et al., Biomed. Biochim. Acta 44 (1985) 7/8, pp. 1201-1210.
Synthese von Na-(Arylsulfonylglycyl)amidinophenylalaninamiden als hochaktive Inhibitoren des Thrombins by G. Wagner et al., Pharmazie 39 (1984) pp. 226-230.
Chemical Abstracts, vol. 110(7): 5094t (1989).
Chemical Abstracts, vol. 110(11): 95774q (1989).
Chemical Abstracts, vol. 111(9): 70596h (1989).
J. Stuerzebecher et al. "Synthetische Inhibitoren der Serinproteinasen," Pharmazie, 42, (1987), pp. 114-121.
D. Horn et al., "Synthese von N .alpha.-(8-Chinolonsulfonyl)-4-amidino-phenylalaninamiden Throbininhibitoren," Pharmazie, 40, (1985), pp. 615-616.

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