Amidinophenylalanine derivatives as thrombin inhibitors

Details Amidinophenylalanine derivatives as thrombin inhibitors Amidinophenylalanine derivatives as thrombin inhibitors

2007-10-23

2007-10-23

Coleman, Brenda (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S217110, C540S597000, C540S607000

Reexamination Certificate

active

10433358

ABSTRACT:
The compounds of the formula (formula 1) and pharmaceutically acceptable salts thereof and a process for preparing the same and pharmaceutical compositions containing the same are described wherein the substituents have the meaning as specified in the description. The compounds are used as thrombon inhibitors.

REFERENCES:
patent: WO95/13274 (1995-05-01), None
Zega, et al., 2001, “Design and Structure-Activity Relationship of Thrombin Inhibitors with an Azaphenylalanine Scaffold: Potency and Selectivity Enhancements Via P2 Optimization,”Bioorg. Med. Chem., vol. 9, pp. 2745-2756, Pergamon Press.
Oh, et al., 1998, “Discovery of LB30057, A Benzamidrazone-based Selective Oral Thrombin Inhibitor,”Bioorg. Med. Chem. Lett., vol. 8, pp. 631-634, Pergamon Press.
Kim, et al., 1997, “Rational Design of Selective Thrombin Inhibitors,” Bioorg. Med. Chem. Lett., vol. 7, No. 7, pp. 769-774, Pergamon Press.

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