Amidinophenylalanine derivatives, a process for the preparation

Details Amidinophenylalanine derivatives, a process for the preparation Amidinophenylalanine derivatives, a process for the preparation

1994-01-25

1995-10-10

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514210, 514212, 514326, 514330, 514381, 514382, 514419, 514456, 514603, 540200, 540453, 540607, 546205, 546226, 546 22, 548253, 548540, 549398, 564 86, A61K 3702, C07K 506

Patent

active

054571146

ABSTRACT:
Amidinophenylalanine derivatives of the formula I ##STR1## the synthesis of these compounds, the use thereof and pharmaceutical agents which contain these compounds are described.

REFERENCES:
patent: 4537896 (1985-08-01), Claesson
patent: 4791102 (1988-12-01), Bernat
Wilbraham et al "Organic and Biological Chemistry" Benjamin/Cummings Publishing, 1984, pp. 222-225.
J. Stuerzebecher et al. "Synthetische Inhibitoren der Serinproteinasen," Pharmazie, 42, 1987, pp. 114-121.
D. Horn et al., "Synthese van N.alpha.-(8-Chinolonsulfonyl)-4-amidinophenylalaninamiden Thrombininhibitoren," Pharmazie, 40, 1985, pp. 615-616.
Synthesis of 2-Amino-3-Boronopropionic Acid: A Boron-containing Analogoue of Aspartic Acid, D. H. Kinder et al., J. Orig. Chem. (1987), 52, pp. 2352-2454.
The Synthesis And Structure of some N-(L-aspart-4-oyl)-.beta.-D-xylopyranosylamine Derivatives, Rita Walczyna and Janusz Sokolowski, Carbohydrate Research, 180 (1988) pp. 147-151.
Synthesis Of Glycosylmides And 4-N-Glycosyl-L-Asparagine Derivatives, Anatoly Ya. Khorlin et al., Carbohydrate Research, 85 (1980) pp. 201-208.
Eine Einfache Synthese Von N-Acyl-Glykosylaminen, Almuth Klemer and Michael Kohla, J. Carbohydrate Chemistry, 7(4) (1988) pp. 785-797.
Synthesis The .alpha. and .beta. anomer of An N-triglycosyl Dipeptide, T. Takeda et al., Carbohydrate Research, 201, (1990), pp. 71-79.
Solid-Phase Synthesis Of Gylcopeptides: Synthesis Of N.sup..alpha. Fluorenylmethoxycarbonyl L-Asparagine N.beta.- Glycosides, Laszlo Urge et al., Tetrahedron Letters, vol. 32, No. 29 (1991) pp. 3445-3448.
Selective Inhibition Of Thrombin By (2R,4R)-4-Methyl-1-[N.sup.2 -[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl)]-2-piperd inecarboxylic Acid, Ryoji Kikumoto et al., Biochemistry vol. 23, No. 1 (1984) pp. 85-90.
Anticoagulant Therapy With MD805 Of A Hemodialysis Patient With Heparin-Induced Thrombocytopenia, T. Matsuo et al., Thrombosis Research 58, 1990, pp. 663-666. pp. 1201-1210.
Pharmacological Characterization Of A New Highly Effective Synthetic Thrombin Inhibitor, B. Kaiser et al., Biomed. Biochim. Acta 44, (1985) 7/8, pp. 1201-1210.
Pharmacological Characterization Of A New Structural Variant of 4-Amidinophenylalanine Amide-type Synthetic Trombin Inhibitor, J. Hauptmann et al., Pharmazie 44 (1989) pp. 282-284.

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