Amidinophenol derivatives

Details Amidinophenol derivatives Amidinophenol derivatives

1995-06-05

1997-03-25

Gupta, Yogendra N.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514415, 514539, 514541, 548510, 560 24, 560 34, 560 35, 560 39, A61K 31165, A61K 3124, C07C22936, C07C27118

Patent

active

056145551

ABSTRACT:
Amidinophenol derivatives of the formula (I) ##STR1## wherein the various symbols are as defined herein; which have inhibitory activities on PLA.sub.2 and on various proteases such as trypsin, plasmin, thrombin, kallikrein, especially trypsin, and are useful for the prevention and/or the treatment of various inflammatory diseases, allergic diseases, disseminated intravascular coagulation, pancreatitis, severity in pancreatitis and multiple organ failure.

REFERENCES:
patent: 4514416 (1985-04-01), Fujii et al.
patent: 4570006 (1986-02-01), Fujii et al.
Japan J. Pharmacol., 52, 23-34, 1990, , Oda et al., "Pharmacological Studies on 6-Amidino-2-Naphthyl[4-(4,5-dihydro-1 H-Imidazol-2-yl)amino]Benzoate Dimethane Sulfonate (FUT-187). I: Inhibitory Activities on Various Kinds of Enzymes in Vitro and Anticomplement Activity In Vivo".

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