Amidinophenol derivatives

Details Amidinophenol derivatives Amidinophenol derivatives

1994-12-02

1996-05-07

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560 35, 560 42, A61K 31235

Patent

active

055147135

ABSTRACT:
Disclosed are amidinophenol derivatives of the formula (I) and acid-addition salts thereof (in which R.sup.1 and R.sup.2 are alkyl, alkoxy, acyl, halogen, nitro, benzoyl, COOR.sub.4 ; A is bond, alkylene, group of the formula (II); R.sup.3 is group of the formula (III), (IV)) ##STR1## Compounds of the formula (I) have inhibitory activities on phospholipase A.sub.2 and proteases (especially trypsin), and are useful for the prevention and/or the treatment of inflammatory diseases, allergic diseases, disseminated intravascular coagulation, pancreatitis, severity in pancreatitis and multiple organ failure.

REFERENCES:
patent: 2868691 (1959-01-01), Porush et al.
patent: 3095355 (1963-06-01), Abramson et al.
patent: 4514416 (1985-04-01), Fuji et al.
patent: 4570006 (1986-02-01), Fuji et al.

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