Amidinoindoles, amidinoazoles, and analogs thereof

Details Amidinoindoles, amidinoazoles, and analogs thereof Amidinoindoles, amidinoazoles, and analogs thereof

1998-10-21

2000-03-28

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5462757, 5462734, 5462737, 5483094, 5483625, 548491, 548484, 549467, 549 58, 514397, 514399, 514400, A01N 4340, A01N 4338, C07D40112, C07D23526

Patent

active

060432578

ABSTRACT:
The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula I: ##STR1## wherein W, W.sup.1, W.sup.2, and W.sup.3 are selected from CH and N, provided that one of W.sup.1 and W.sup.2 is C(C(.dbd.NH)NH.sub.2) and at most two of W, W.sup.1, W.sup.2, and W.sup.3 are N and one of J.sup.a and J.sup.b is substituted by --(CH.sub.2).sub.n --Z--A--B, which are useful as inhibitors of factor Xa or thrombin.

REFERENCES:
patent: 5328920 (1994-07-01), Effland et al.
Tidwell et al, Journal of Medicinal Chemistry, 1983, 26, 294-298, "Aromatic Amidines: Comparison of Their Ability to Block Respiratory Syncytial Virus Induced Cell Fusion and to Inhibit Plasmin, Urokinase, Thrombin, and Trypsin."
Fairley et al, Journal of Medicinal Chemistry, 1993, 36, 1746-1753, "Structure, DNA Minor Groove Binding, and Base Pair Specificity of Alkyl-and Aryl-Linked Bis (amidinobenzimidazoles) and Bis (amidinoindoles). "
Geratz et al, Thrombosis Research, 1981, 24, 73-83, "Inhibitory Effect of Amidino-Substituted Heterocyclic Compounds on The Amidase Activity of Plasmin and of High and Low Molecular Weight Urokinase and on Urokinase-Induced Plasminogen Activat ion. "

Affiliated with

Also associated with

Rating

Amidinoindoles, amidinoazoles, and analogs thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amidinoindoles, amidinoazoles, and analogs thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amidinoindoles, amidinoazoles, and analogs thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1326320