Amidino derivatives useful as nitric oxide synthase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

5142242, 5142305, 514258, 514309, 514312, 514313, 544 47, 544 48, 544 50, 544 90, 544 91, 544 92, 544253, 546113, 546141, 546143, 546153, 546159, A61K 3147, C07D21722, C07D21538

Patent

active

060462116

ABSTRACT:
The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.

REFERENCES:
patent: 2049582 (1936-08-01), Ziegler
patent: 3109848 (1963-11-01), Bortnick et al.
patent: 3121093 (1964-02-01), Bortnick et al.
patent: 3132151 (1964-05-01), Bortnick et al.
patent: 3501487 (1970-03-01), Poos
patent: 3563994 (1971-02-01), Wollweber et al.
patent: 3694432 (1972-09-01), Hershenson
patent: 3725435 (1973-04-01), Poos
patent: 3816457 (1974-06-01), Grisar et al.
patent: 4046909 (1977-09-01), Rasmussen et al.
patent: 4061746 (1977-12-01), Blohm et al.
patent: 4126613 (1978-11-01), Grisar et al.
patent: 4126621 (1978-11-01), Grisar et al.
patent: 4153235 (1979-05-01), Grisar et al.
patent: 4443468 (1984-04-01), Maillard et al.
patent: 4523020 (1985-06-01), Moormann et al.
patent: 4525476 (1985-06-01), Butler et al.
patent: 4533739 (1985-08-01), Pitzele et al.
patent: 4556674 (1985-12-01), Maillard et al.
patent: 4579951 (1986-04-01), Pitzele et al.
patent: 4699918 (1987-10-01), Maillard et al.
patent: 4855444 (1989-08-01), Wambach
patent: 4962204 (1990-10-01), Wambach
patent: 5028627 (1991-07-01), Kilbourn et al.
patent: 5051444 (1991-09-01), Tamoto et al.
patent: 5059712 (1991-10-01), Griffith
patent: 5081148 (1992-01-01), Braquet et al.
patent: 5132453 (1992-07-01), Griffith
patent: 5196439 (1993-03-01), Sugimoto et al.
patent: 5216025 (1993-06-01), Gross et al.
patent: 5246971 (1993-09-01), Williamson et al.
patent: 5266594 (1993-11-01), Dawson et al.
patent: 5273875 (1993-12-01), Griffith
patent: 5621004 (1997-04-01), Dunn et al.
patent: 5629322 (1997-05-01), Guthikonda et al.
Armarego et al., Purine Studies. Part XX. Methylation and Reduction of 2,8-Dioxo-, 2,8-Diamino-, and 2-Amino-8-oxo-purines, and the Sterochemistry of their 1,4,5,6-Tetrahydro-derivatives, Journal of the Chemical Society, Perkin Transactions I, vol. 13, 1976.
Armarego et al., Quinazolines. Part XXI. Synthesis of cis-2-Amino-8a-carboxymethyl-3,4,4a,5,6,7,8,8a-octahydroquinazoline and Related Compounds. Conversion of Perhydroaquinazolin-2-ones into 2-Amino-3,4,4a,5,6,7,8,8a-octahydroquinazolines, Journal of th, 1975.
Armarego et al., Quinazolines. Part XV. Hexahydro- and Octahydro-quinazolines, Journal of the Chemical Society (C), vol. 2, pp. 238-245, 1971.
Armarego et al., Quinazolines. Part XIV. The Absolute Configurations of cis- and trans-(+)- and (-)-Decahydroquinazolines and 2-Amino-octahydroquinazolines, Journal of the Chemical Society (C), vol. 11, pp. 1597-1600, 1970.
Culvenor, C.C.J. et al, Aust. J. Chem., 24 (1971) 371-375 (Beilstein Registry ID Only).
Caujolle, R. et al, Eur. J. Med. Chem. Chim. Ther., 28(1) (1993) 29-35 (Beilstein Registry ID Only).
Kato et al, Chem. Pharm. Bull., 20 (1972) 901 (Beilstein Registry ID Only).
Anderson, Wayne K. et al, Synth. Commun., 19(13-14) (1989) 2237-2242 (Beilstein Registry ID Only).
Olomucki et al, Biochim. Biophys. Acta, 263 (1972) 213, 215, 216 (Beilstein Registry ID Only).
Otake, N. et al, Tetrahedron Lett., 19 (1965) 1411-1419 (Beilstein Registry ID Only).
Patent: Kerin Seiyaku Kabushiki Kaisya, JP, A, 17189, 1968; Referati vnyi Zhurnal. Kimiya., 1 (1970) N469P (Beilstein Registry ID Only).
Umezawa et al, J. Antibiot., 26 (1973) 625, 637 (Beilstein Registry ID Only).
Marconi et al, J. Antibiot., 23 (1970) 120, 121, 122, 123 (Beilstein Registry ID Only).
Kretow et al, J. Gen. Chem. USSR, 32 (1962) 464 (Beilstein Registry ID Only).
Dorn et al, Chem. Ber., 103 (1970) 2505, 2506, 2508, 2511 (Beilstein Registry ID Only).
Andrewes et al, Proc. R. Soc. London B, 133 (1946) 20, 53 (Beilstein Registry ID Only).
Schubert, H. W. et al, Arch. Pharm. Ber. Dtsch. Pharm. Ges., 301(10) (1968) 750-762 (Beilstein Registry ID Only).
Stefanye et al, J. Amer. Chem. Soc., 77 (1955) 761 (Beilstein Registry ID Only).
Goodman et al, J. Org. Chem., 23 (1958) 1954, 1956, (Beilstein Registry ID Only).
Goodman et al, J. Org. Chem., 23 (1958) 1251, 1252, 1255, 1954, 1956 (Beilstein Registry ID Only).
Bertolini et al., "Nitric Oxide Synthase Inhibitors: Recent Advances", Cardiovascular & Renal Patent Update, Ashley Publications Ltd., pp. 1339-1345, 1994.
Perrin et al., "Absence of Stereoelectronic Control in Hydrolysis of Cyclic Amidines", J. Am. Chem. Soc., vol. 108, No. 19, pp. 5997-6003, 1986.
Huber et al., "Saturated Heterocycles, Part 88. Synthesis of a New Ring System: Dipyrido-[1.2-a:4,3-d]pyrimidin-11-one Derivatives", J. Chem. Soc. Perkin Trans. 1, pp. 909-912, 1987.
Kokosi et al., "Nitrogen Bridgehead Compounds. Part 19(1). Synthesis of Polymethylenepyrimidin-4-ones", J. Heterocyclic Chem., vol. 19, pp. 909-912, 1982.
Brown et al., Hydropyrimidines, Part II, pp. 4041-4045, 1962.
Adcock et al., 2-Amino-2-imidazolines 2-Amino-2-oxazolines, Part II, pp. 474-479, 1965.
Stefanye et al., "Cyclic Guanidines from Nitrimino Compounds", J. Am. Chem. Soc., vol. 77, No. 3, pp. 761-762, 1955.
Klayman et al., "2-Amino-2-thiazoline. VII. Unequivocal Structure Assignment of the Products of the Reaction of 2-Amino-2-thiazoline and Its Analogs with Carbethoxy Isothiocyanate", J. Org. Chem., vol. 39, No. 13, pp. 1819-1823, 1974.
Moriconi et al., "Synthesis and Reactions of Cyclic Amidines", J. Org. Chem., vol. 33, No. 5, pp. 2109-2111, 1968.
Wagenaar et al., "Methodology for the Preparation of N-Guanidino-Modified Arginines and Related Derivatives", J. Org. Chem., vol. 58, No. 1, pp. 4331-4338, 1993.
Gutteridge, "Acylation of 2-Amino-5,5-dimethyl-.DELTA.-pyrroline 1-Oxide", J. Chem. Soc., (C), pp. 3121-3125, 1971.
Langlois et al., "Derivatives of Imidazole, 1,3,4-triazole and tetrazole", J. Heterocycl. Chem., vol. 19, No. 1, pp. 193-200, 1982 (English Summary, p. 200).
Langlois et al., "Synthesis and Antidepressant Properties of 2-Amino-phenyl-1-pyrroline Derivatives", Eur. J. Med. Chem., vol. 13, No. 2, pp. 161-169, 1978 (English Summary, p. 169).
Klotzer et al. "Acylderivatives of 2-Amino-1-pyrrolines", Monatshefte fur Chemie, vol. 102, No. 2, pp. 627-634, 1971 (English Summary, p. 627).
Klotzer et al. "Synthesis of Substituted 2-Amino-1-pyrrolines, I." Monatshefte fur Chemie, vol. 101, No. 5, pp. 1263-1270, 1979 (English Summary, p. 1263).
Nakane et al., "Novel Potent and Selective Inhibitors of Inducible Nitric Oxide Synthase", Molecular Pharmacology, vol. 47, pp. 831-834, 1995.
Dunbar et al., "Design, Synthesis, and Neurochemical Evaluation of 2-Amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydopyridines and 2-Amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M.sub.1 Muscarinic Receptor Agonists", J. Med. Chem., vol. 37, No. 17, pp. 2774-2782, 1994.
Klotzer et al. "Synthesis of Substituted 2-Aminopyrrolines, II." Monatshefte fur Chemie, vol. 101, No. 6, pp. 1841-1850, 1970 (English Summary, p. 1841).
Berge et al., "Pharmaceutical Salts", J. Pharm. Sci., vol. 66, No. 1, pp. 1-19, 1977.
Moncada et al., "Nitric Oxide: Physiology, Pathophysiology, and Pharmacology", Pharmacological Reviews, Vo. 43, No. 2, pp. 109-142, 1991.
Moncada et al, "Biosynthesis of Nitric Oxide from L-Arginine", Biochemical Pharm., Vol 38, No. 11, pp. 1709-1715, 1989.
Mazurek et al., "Theoretical Studies of Tautomerism of Clonidine Vacuum and in Water Medium", Theochem, 82(1-2), 23-8, 1991.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Amidino derivatives useful as nitric oxide synthase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amidino derivatives useful as nitric oxide synthase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amidino derivatives useful as nitric oxide synthase inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-365580

All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.