Amidino compounds

Details Amidino compounds Amidino compounds

1975-02-19

1977-07-19

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

2602948G, 2602948D, 2603067R, 2603068R, 2603068D, 2603068A, 260307H, 260308R, 260308A, 260309, 2603096, A61K 31415, C07D23364

Patent

active

040369714

ABSTRACT:
The compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkyl-isothioureas. The compounds may also have N'-lower alkyl or N'-(heterocyclomethylthioalkyl)substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]N"-methylguanidine. The compounds of this invention are histamine H.sub.2 -antagonists.

REFERENCES:
patent: 3734924 (1973-05-01), Black et al.
patent: 3736331 (1973-05-01), Black et al.
Derwent Abstract No. 19437V of Belgian patent 804,144 (patent published Feb. 28, 1974 - Smith, Kline & French).
Derwent Abstract No. 19438V of Belgian patent 804,145 (patent published Feb. 28, 1974 - Smith, Kline & French).

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