Amidine derivatives with anti-complement activity

Details Amidine derivatives with anti-complement activity Amidine derivatives with anti-complement activity

1982-04-21

1985-01-29

Waltz, Thomas A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514529, 514546, 514549, 514551, 514552, 2604045, 2604105, 260 1, 260122, 260123, 260124, 260125, 260128, 260138, 260139, 260163, 260168, 260169, 260171, 260173, 260221, 260251, 260134, C11C 304, C07C 69035, A61K 3127, A61K 3123

Patent

active

044965842

ABSTRACT:
Amidino compounds represented by the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsin, antiplasmin, antikallikrein and antithrombin agents. Having strong anti-Cl activity and anti-complement activity, they are also useful as anti-complement agents. These amidino compounds are prepared by reacting carboxylic compounds represented by the formula

REFERENCES:
Pharmazie, 32(12), (1977), pp. 761-763, Wagner et al. (I), "Synthetische Inhibitoren der Serinproteinasen".
Chemical Abstracts, vol. 90, No. 5, Abstract No. 38710c, (1979), p. 468, Wagner et al. (II).
Pharmazie, 34(9), (1979), pp. 554-556,, Labes et al., "Free-Wilson-Arylyse der Hemmirkung Von 4-substituierten Benzamidinen gegenuber Thrombin, Plasminund Tryissin".

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