Amidine derivatives and cardiotonic compositions

Details Amidine derivatives and cardiotonic compositions Amidine derivatives and cardiotonic compositions

1984-12-14

1986-07-01

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514236, 514237, 514255, 514357, 514399, 514401, 514517, 514539, 514554, 514564, 514565, 514637, 544162, 544398, 546278, 546332, 548335, 548347, 548355, 560 21, 560 34, 560 35, 562435, 562439, 562440, 564226, 564246, 26050114, A61K 31155, A61K 31535, C07C12300, C07D29514

Patent

active

045980772

ABSTRACT:
Amidine derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, represent each a hydrogen atom or a lower alkyl group, or R.sub.1 and R.sub.2 together with an intermediary carbon atom and/or hetero atom may form a ring; X represents ##STR2## (wherein R.sub.8 represents a hydrogen atom, a lower alkyl group, or --CH.sub.2 COOR.sub.9, where R.sub.9 represents a hydrogen atom or a lower alkyl group; Z represents a single bond, --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, or --CH.dbd.CH--); R.sub.3 represents a hydrogen or chlorine atom, methoxy group, nitro group, or amino group; Y represents --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CH.sub.2 O--, or --OCH.sub.2 --; R.sub.4 represents a hydrogen atom, methoxy group, benzoyl group, nitro group, or amino group; and R.sub.5, R.sub.6 and R.sub.7, which may be the same or different, represent each a hydrogen atom, lower alkyl group, cycloalkyl group, aralkyl group, substituted alkyl group, substituted aralkyl group, or amino group, or R.sub.5 and R.sub.7 may form a ring, or salts thereof have an excellent cardiotonic activity and can be used as cardiotonics.

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