Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1982-05-11
1988-05-31
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514245, 514247, 514252, 514269, 514333, 544182, 544211, 544212, 544238, 544239, 544240, 544241, 544284, 544296, 544298, 544311, 544326, 544327, 544328, 544329, 544330, 544336, 546261, 546264, 546290, 546296, 546297, 546306, 548127, 548128, 548131, 548134, 548136, 548143, 548202, 248203, 548204, 548205, 548252, 548255, 548263, 548264, 548265, 548266, 548269, 548329, 548376, 548378, A61K 31505, C07D23942
Patent
active
047481650
ABSTRACT:
This invention relates to amidine derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of the formula I: ##STR1## in which R.sup.1 is hydrogen or a 1-10C alkyl, 3-8C cycloalkyl, 4-14C cycloalkylalkyl, 3-6C alkenyl, 3-6C alkynyl, 1-6C alkanoyl, 6-10C aryl, 7-11C aralkyl or 7-11C aroyl radical, the latter three being optionally substituted; ring X is a heterocyclic ring as defined in the specification; A is phenylene or 5-7C cycloalkylene or a 1-8C alkylene chain into which is optionally inserted one or two groups; and R.sup.2 and R.sup.3 are a variety of radicals described in the specification: and the pharmaceutically-acceptable acid-addition salts thereof. Manufacturing processes and pharmaceutical compositions are also described.
REFERENCES:
patent: 4165377 (1979-08-01), Jones et al.
patent: 4165378 (1979-08-01), Gilman et al.
patent: 4242350 (1980-12-01), Yellin et al.
patent: 4242351 (1980-12-01), Yellin et al.
patent: 4252819 (1981-02-01), Hirata et al.
patent: 4362728 (1982-12-01), Yellin et al.
Jones Derrick F.
Oldham Keith
Hollrah Glennon H.
Imperial Chemical Industries plc
Turnipseed James H.
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