Amidine compounds and anticomplement agent comprising same

Details Amidine compounds and anticomplement agent comprising same Amidine compounds and anticomplement agent comprising same

1984-01-20

1985-07-30

Helfin, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

260465D, 560 9, 560 12, 560 19, 560 20, 560 34, 560 48, 560105, 560107, 514522, 514540, 549442, C07C10100, C07C10148, A61K 3134

Patent

active

045322554

ABSTRACT:
Amidino compounds represented by the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsine, antiplasmin, antikallikrein and antithrombin agents. Having strong anti-C1 (C1r, C1s) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula ##STR2## with 6-amidino-2-naphthol and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof.

REFERENCES:
patent: 4021472 (1977-05-01), Fujii et al.
patent: 4454338 (1984-06-01), Fujii et al.
Wagner et al., Pharmazie, vol. 32, H 12, (1977), 761-763.

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