Amidine compound and anticomplement agent comprising same

Details Amidine compound and anticomplement agent comprising same Amidine compound and anticomplement agent comprising same

1982-02-22

1984-12-25

Helfin, Bernard

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

424304, 424309, 424310, 424311, 424314, 260465D, 549436, 549438, 560 1, 560 18, 560 20, 560 24, 560 27, 560 34, 560 49, 560 51, 560 64, 560 72, 560 86, 560104, 560105, 560109, 560122, 560123, 560124, 560125, 560126, 560127, 560128, C07C10100, A61K 31215

Patent

active

044903880

ABSTRACT:
Amidino compounds represented by the formula (I) ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsine, antiplasmin, antikallikrein and anti-thrombin agents. Having strong anti-Cl (Clr, Cls) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula (II)

REFERENCES:
patent: 3579510 (1971-05-01), McFarland
patent: 4021472 (1977-05-01), Fujii et al.
patent: 4224342 (1980-09-01), Fujii et al.

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