Amidine compound

Details Amidine compound Amidine compound

1981-09-09

1984-06-12

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 17, 560 12, 560 73, 560 49, 560 37, 560 20, 560 86, 560 67, 560107, 260465D, 424304, 424309, 424282, C07C10100, C07C10148

Patent

active

044543387

ABSTRACT:
Amidino compounds represented by the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsine, antiplasmin, antikallikrein and antithrombin agents. Having strong anti-C1 (C1r, C1s) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula ##STR2## with 6-amidino-2-naphthol and, if necessary, can be transformed into pharmaceuticlly acceptable acid addition salts thereof.

REFERENCES:
patent: 4021472 (1977-05-01), Fujii et al.
Wagner et al., Pharmazie, vol. 32 (1977), H12, pp. 761-763.
Takada et al., Immunology, vol. 34 (1978), pp. 509-515.
Wagner et al., (I), Pharmazie, 28(5) (1973), 293-296.

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