Amidine benzodiazepines, methods for their use and intermediates

Details Amidine benzodiazepines, methods for their use and intermediates Amidine benzodiazepines, methods for their use and intermediates

1984-04-11

1985-10-15

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

260239BD, 2602393P, 2602444, 2602457, A01N 4384, A01N 4348, A01N 4340, C07D21000

Patent

active

045474974

ABSTRACT:
Fused tetracyclic benzodiazepines of the formula (I): ##STR1## where R.sup.1 is an acyclic amine or cyclic amine such as 1-piperidine, 4-morpholine or 1-piperazine and R.sup.2 is H or a substituent as defined herein as useful as antiallergins. Also, methods for their synthesis, intermediate used in such synthesis, methods for use as medicaments and pharmaceutical compositions.

REFERENCES:
patent: 3980797 (1976-09-01), Jonas et al.
patent: 4117129 (1978-09-01), Brown
patent: 4427588 (1984-01-01), Kaneko et al.
patent: 4472414 (1984-09-01), Glamkowski
Chemical Abstracts 95(15):132843y, Gatta et al, Synthesis of Indoloquinazolines, Indolo[-1,4]Benzodiazepines, (1981).
Garcia et al, Acyl Indoles II. Indolo[2,1-b]Quinazolones, Journal Heterocyclic Chem. 7(5), 1161-3, (1970), CA74(5),22805w.
Duncan, Jr. et al, Synthesis of Indolo and Benzimidazoquinazolines, J. Heterocyclic Chem. 10(1), 65-70, (1973), CA:78(17):11272v.
Walker et al, Novel Synthesis of 1,4 Benzodiazepines, J. Org. Chem. 37(24), 3755-70, CA78(3):16150w, (1972).
E. E. Garcia, Chemical Research Department, Hoffman LaRoche, Inc., pp. 1161-1163, (Oct. 1970).
William B. Wright, Jr., American Chemical Society, pp. 462-465, (1980).

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