Amides useful for treating pain

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S256000, C514S333000, C544S333000, C546S256000, C546S257000

Reexamination Certificate

active

07348343

ABSTRACT:
The present invention relates to compounds of formula (I-VII)or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R6, R7and R8are defined herein. The present invention also relates to methods of treating pain using these compounds and pharmaceutical compositions including these compounds.

REFERENCES:
patent: 1 437 344 (2004-07-01), None
patent: 2003/192673 (2003-07-01), None
patent: 02/08221 (2002-01-01), None
patent: 03/066595 (2003-08-01), None
patent: 03/074520 (2003-09-01), None
patent: 2004/011441 (2004-02-01), None
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Caterina, et al., “The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway,”Annual Review of Neuroscience24:487-517 (2001).
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Database Chemcats Apr. 23, 2003, retrieved from STN Database accession No. 2003: 3693665; 2003:3693659, 2003: 3693658 and other compounds from AsInEx Express Platinum Collection abstract.
Davis, et al., “Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia,”Nature405:183-187 (2000).
Fowler, “Intravesical treatment of overactive bladder,”Urology55(Supp 5A):60-64 (2000).
Hayes, et al., “Cloning and functional expression of a human orthologue of rat vanilloid receptor-1,” Pain 88:205-215 (2000).
Nolano, et al., “Topical capsaicin in humans: parallel loss of epidermal nerve fibers and pain sensation,”Pain81:135-145 (1999).
Pircio, A New Method for the Evaluation of Analgesic Activity using Adjuvant-Induced Arthritis in the Rat, European J. of Pharmacology, V 31 pp. 207-215 (1975).
Poste, Lipid Vesicles as Carriers for Introducing Biologically Active Materials into Cells, Methods in Cell Biology, vol. XIV, pp. 33-71 (1976).
Patent Abstracts of Japan, vol. 2003, No. 11, Nov. 2003.

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