Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-10-17
2006-10-17
Saeed, Kamal A. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07122683
ABSTRACT:
A compound of Formula (I)and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein:R1, R2, R3and R20are each independently H, Cl, Br, F, I, CF3, OCF3, Me or Et;R4is het or C3-7cycloalkyl optionally substituted by C1-4alkyl, C1-4alkoxy, alkoxyalkyl containing 2 to 4 carbon atoms or —S—(C1-4alkyl);a is 0 or 1; andhet is a non-aromatic 4-, 5- or 6-membered heterocycle which contains at least one N, O or S heteroatom, optionally fused to a 5- or 6-membered carbocyclic group or a second 4-, 5- or 6-membered heterocycle which contains at least one N, O or S heteroatom, wherein the het group is optionally substituted by at least one substituent independently selected from C1-8alkyl, C1-8alkoxy, OH, halo, CF3, OCF3, SCF3, hydroxy-C1-6alkyl, C1-4alkoxy-C1-6alkyl and C1-4alkyl-S—C1-4alkyl; provided that at least one of R1, R2and R3are other than H. The compounds of the invention exhibit activity as both serotonin and noradrenaline re-uptake inhibitors and therefore have utility in a variety of therapeutic areas, for example urinary incontinence.
REFERENCES:
patent: 3577440 (1971-05-01), Lunsford et al.
patent: 628885 (1978-01-01), None
patent: WO 2004110995 (2004-12-01), None
patent: WO 2004111003 (2004-12-01), None
patent: WO 2005047251 (2005-05-01), None
Norman, Trevor, R., et al.,New Pharmacological Approaches to the Management of Depression: From Theory to Clinical Practice;Australian and New Zealand Journal of Psychiatry, 1992, 26:73-81.
Fish Paul Vincent
Ryckmans Thomas
Stobie Alan
Wakenhut Florian
Whitlock Gavin Alistair
Benson Gregg C
Goddard Carl J.
Pfizer Inc.
Saeed Kamal A.
Young Shawquia
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