Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1976-08-16
1978-10-24
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
424247, 424267, 542421, 544 39, 26029371, 26032633, 26032634, 26032643, A61K 3140
Patent
active
041221990
ABSTRACT:
New chemical compounds, which are pyrrolidinoethylamine amides, in the form of free bases and salts thereof, which are useful as antitussives, pharmaceutical compositions thereof, and method of treating therewith.
In the form of their salts, the compounds have the formula: ##STR1## wherein ##STR2## is an acyl radical of a phenylacetic, 60 -phenyl-.alpha.-(1 to 5 C atoms) acetic, (1 to 5 C atoms) diphenylacetic, benzilic, diphenyl-.alpha.-chloroacetic, .alpha.-lower-alkoxy-.alpha.,.alpha.-diphenylacetic, 3-coumarincarboxylic, 9-xanthenecarboxylic, phenoxyacetic, phenoxyisobutyric, halophenoxyisobutyric, or 9-flourene carboxylic acid, and wherein R'H represents an inorganic or organic acid.
Medicaments containing these active principles may be used, inter alia, in the treatment of coughs and respiratory complaints.
REFERENCES:
patent: 2627517 (1953-02-01), Cusic
patent: 2634274 (1953-04-01), Krimmel
patent: 2862965 (1958-12-01), Lott et al.
patent: 2932645 (1960-04-01), Taylor et al.
patent: 3074939 (1963-01-01), Davis
patent: 3455940 (1969-07-01), Stecker
Weitzel et al, Chemical Abstracts, vol. 61, col. 4864b (1964) (abst. of Weitzel et al, Z. Physiol. Chem. vol. 336 pp. 107-126 (1964).
Bonnaud Bernard
Casadio Silvano
Cousse Henri
Tarayre Jean-Pierre
Hueschen Gordon W.
Jiles Henry R.
Pierre Fabre S.A.
Ramsuer R. W.
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