Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-06-26
1988-03-15
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514328, 514331, 514424, 514245, 514428, 548543, 548544, 548546, 548550, 548556, 548567, 548569, 546232, 546233, 546235, 546220, 546221, C07D20712, C07D21140, A61K 31445, A61K 3140
Patent
active
047313692
ABSTRACT:
Amides and esters of 2-[N-(hydroxypiperidinoalkyl) and (hydroxypyrrolidinoalkyl) aminosulfonyl]-6-nitrobenzoic acids are disclosed to have activity in increasing the sensitivity of hypoxic tumor cells to therapeutic radiation. Also disclosed are methods of preparing such compounds, pharmaceutical compositions including such compounds and methods of treating patients in need of therapeutic radiation with effective amounts of such compounds.
REFERENCES:
patent: 4132786 (1979-01-01), Moreau et al.
patent: 4396622 (1983-08-01), Jozic
patent: 4603133 (1986-07-01), Engelhardt et al.
Wardman, Radiat. Phys, Chem., vol. 24, pp. 293-305 (1984).
Engelhardt Edward L.
Saari Walfred S.
Abrams S. B.
Ford John M.
Merck & Co. , Inc.
Meredith R. D.
Pfeiffer H. J.
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