Amide type carboxamide derivative

Details Amide type carboxamide derivative Amide type carboxamide derivative

2008-05-20

2008-05-20

Andres, Janet L. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S357000, C546S337000, C544S111000

Reexamination Certificate

active

07375119

ABSTRACT:
The present invention provides an amide-type carboxamide derivative of the formula [1]:wherein X is a group of the formula: —N═ or the formula: —CH═; R1is a halogen atom, a lower alkyl group, and the like; R2is a group of the formula:and the like; Y1and Y2are the same or different and each is a group selected from a halogen atom, a lower alkyl group, a lower alkoxy group, and the like; Ring A is phenyl group, and the like, or a pharmaceutically acceptable salt thereof, which is useful as an inhibitor of FXa.

REFERENCES:
patent: 6380221 (2002-04-01), Arnaiz et al.
patent: 2003/0026521 (2003-02-01), Amin et al.
patent: 2003/0069250 (2003-04-01), Zhu et al.
patent: 2004/0029874 (2004-02-01), Beight et al.
patent: WO-99/00121 (1999-01-01), None
patent: WO-99/42439 (1999-08-01), None
patent: WO-00/39118 (2000-07-01), None
patent: WO-01/19788 (2001-03-01), None
patent: WO-02/12189 (2002-02-01), None
patent: WO-02/019145 (2002-10-01), None
patent: WO-02/079145 (2002-10-01), None
patent: WO-03/082847 (2003-10-01), None
patent: WO-04/063202 (2004-07-01), None
patent: WO-2004/063202 (2004-07-01), None
Ying, K. Yee et al., Journal of Medicinal Chemistry, 2000, vol. 43, NO. 5, pp. 873-882.
Freedman, “Oral Anticoagulants: Pharmacodynamics, Clinical Indications and Adverse Effects”, Journal of Clinical Pharmacology, vol. 32, pp. 196-209, 1992.
Hirsh, “Oral Anticoagulant Drugs”, The New England Journal of Medicine, vol. 324, No. 26, pp. 1865-1875, 1991.
Sixma, et al., “The Ideal Anti-Thrombotic Drug”, Thrombosis Research, Erratum, vol. 68, pp. 507-512, 1992.
Matsuo, “t-PA and Pro-UK”, Gakusaikikaku, pp. 5-40, 1986.
Kaiser, et al., “Pharmacological Characterization of a New Highly Effective Synthetic Thrombin Inhibitor”, Biomedica Biochim Acta, vol. 44, 7/8, pp. 1201-1210, 1985.
Tidwell, et al., “Strategies for Anticoagulation with Synthetic Protease Inhibitors, Xa Inhibitors Versus Thrombin Inhibitors”, Thrombosis Research, vol. 19, pp. 339-349, 1980.
Harwalkar, et al., “Synthesis and Reactions of 2-Substituted-4H-Benzofuro[3,2-d]-m-Oxazin-4-Ones”, Indian Journal of Heterocyclic Chemistry, vol. 3, pp. 247-252, 1994.
Viti, et al., “Synthesis of New Arylbenzofurodiazepin-6-ones”, Journal of Heterocyclic Chemistry, 27(5), pp. 1369-1375, 1990.
Sogorinsho 41, pp. 2913-2918, 1992 (short English summary).
Ying, K. Yee et al., Journal of Medicinal Chemistry, 2000, vol. 43, No. 5, pp. 873-882.

Affiliated with

Also associated with

Rating

Amide type carboxamide derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amide type carboxamide derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amide type carboxamide derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2813884