Amide therapeutic agents

Details Amide therapeutic agents Amide therapeutic agents

1978-04-24

1980-08-12

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548185, C07D27738

Patent

active

042173558

ABSTRACT:
A series of N-(2-thiazolyl)amides has been prepared, including their pharmaceutically acceptable acid addition salts as well as pharmaceutical compositions containing same. These compounds are useful in therapy as anti-inflammatory agents in addition to being useful as immunoregulatory agents for modulating various body immune responses. Preferred member compounds include N-(2-thiazolyl)-.alpha.-methylaminoacetamide, N-(2-thiazolyl)-.alpha.-benzylaminoacetamide, N-(2-thiazolyl)-.alpha.-(p-fluorobenzylamino)acetamide, N-(2-thiazolyl)-.alpha.-(2-thenylamino)acetamide and N-(4-methyl-2-thiazolyl)-.alpha.-amino-.beta.-phenylpropionamide, and their hydrohalide acid addition salts. Three different methods of preparation are provided and these are all described in some detail, including the various synthetic routes leading to the required novel intermediates and/or starting materials.

REFERENCES:
patent: 3553227 (1971-01-01), Westland
patent: 3853862 (1974-12-01), Lombardino
patent: 3862167 (1979-01-01), Veno et al.
patent: 3957812 (1976-05-01), Rossignol et al.
Lombardino et al., Jour. of Heterocyclic Chemistry, vol. 13, p. 333 (1976).

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