Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1980-01-29
1981-12-15
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
42424851, 424270, 424246, 544111, 544 60, 544133, 544195, 544196, 546209, C07D27720
Patent
active
043059490
ABSTRACT:
A series of N-(2-thiazolyl)amides has been prepared, including their pharmaceutically acceptable acid addition salts as well as pharmaceutical compositions containing same. These compounds are useful in therapy as anti-inflammatory agents in addition to being useful as immunoregulatory agents for modulating various body immune responses. Preferred member compounds include N-(2-thiazolyl)-.alpha.-methylaminoacetamide, N-(2-thiazolyl)-.alpha.-benzylaminoacetamide, N-(2-thiazolyl)-.alpha.-(p-fluorobenzylamino)acetamide, N-(2-thiazolyl)-.alpha.-(2-thenylamino)acetamide and N-(4-methyl-2-thiazolyl)-.alpha.-amino-.beta.-phenylpropionamide, and their hydrohalide acid addition salts. Three different methods of preparation are provided and these are all described in some detail, including the various synthetic routes leading to the required novel intermediates and/or starting materials.
REFERENCES:
patent: 3862167 (1975-01-01), Veno et al.
patent: 3957812 (1976-05-01), Rossignol et al.
patent: 3963480 (1976-06-01), Bailey
Bhargava et al., Indian J. Chem., vol. 12, No. 4, pp. 428-429 (1974).
Lombardino et al., Jour. of Heterocyclic Chemistry, vol. 13, p. 333 (1976).
Harbert Charles A.
Lombardino Joseph G.
Pfizer Inc.
Rizzo Nicholas S.
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