Amide tetrazole ACAT inhibitors

Details Amide tetrazole ACAT inhibitors Amide tetrazole ACAT inhibitors

1994-05-27

1995-10-24

Datlow, Philip I.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142278, 5142362, 514241, 514248, 514252, 514256, 514259, 514300, 514310, 514313, 514314, 514326, 514381, 514382, 540603, 544 60, 544132, 544180, 544235, 544237, 544284, 544322, 544328, 544366, 546121, 546122, 546162, 546163, 546171, 546143, 546210, 546276, 548251, 548253, A61K 3141, C07D25704

Patent

active

054610494

ABSTRACT:
Amide tetrazoles of the formula ##STR1## wherein aryl includes phenyl and naphthyl, unsubstituted or substituted, X is .dbd.O, .dbd.N--R.sub.5, or --NR.sub.3 R.sub.4, where R.sub.2, R.sub.4, and R.sub.5 include alkyl and alkoxy and R.sub.3 includes alkyl, are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT) and are thus useful for treating hypercholesterolemia or atherosclerosis.

REFERENCES:
patent: 4540703 (1985-09-01), Uchida et al.
patent: 5015644 (1991-05-01), Roth et al.
patent: 5073565 (1991-12-01), Chucholowski et al.
patent: 5116848 (1992-05-01), Trivedi
Spector, et al., Prog. Lipid Res., vol. 18, pp. 31-53, 1979.

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