Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-11-14
2006-11-14
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S263210, C514S263220, C514S263230, C514S263340, C514S263360, C544S269000, C544S270000, C544S271000, C544S272000, C544S310000, C544S312000, C544S229000, C548S268200, C548S266800, C548S334500, C548S374100
Reexamination Certificate
active
07135475
ABSTRACT:
The present invention is a 1,3,8 substituted xanthine derivative of formula Ior a pharmaceutically acceptable salt thereof, wherein R1, R2and R3are as defined in the specification.Compounds of formula I and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.
REFERENCES:
patent: 2004/0192708 (2004-09-01), Dunten et al.
patent: 2005/0119258 (2005-06-01), Wilson et al.
patent: 2005/0187226 (2005-08-01), Wilson et al.
patent: WO 01 77110 (2001-10-01), None
Definition for “carbamoyl” Stedman's Online Medical Dictionary, 27th Edition <http://216.251.232.159/semdweb/internetsomd/ASP/1499429.asp> download from the Internet Oct. 3, 2005.
DeFronzo et al., Diabetes Reviews, 6, pp. 89-131 (1998).
Shulman, G. I., Am. J. Card., 84 (Suppl.1A), pp. 3J-10J (1999).
Consoli et al., J. Diabetes, 38, pp. 550-557 (1989).
Gastaldelli et al., Diabetes, 49, pp. 1367-1373 (2000).
Cimbala et al., J. Biol. Chem., 257, pp. 7629-7636 (1982).
DeFronzo et al., Diabetes Care, 15, pp. 318-368 (1992).
Müller et al., J. Med. Chem., 36, pp. 3341-3349 (1993).
Papesch et al., J. Org. Chem., 16, pp. 1879-1890 (1951).
Dunten Peter W.
Foley Louise H.
Huby Nicholas J. S.
Pietranico-Cole Sherrie L.
Yun Weiya
Berch Mark L.
Hoffmann-La Roche Inc.
Johnston George W.
Megerditchian Samuel H.
Tramaloni Dennis P.
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