Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxy

Details Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxy Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxy

1991-09-16

1993-04-20

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514278, 544230, 546 17, A61K 31495, C07D47100, C07D40112

Patent

active

052043495

ABSTRACT:
Compounds of the formula: ##STR1## where R.sup.1 is hydrogen or hydroxy and R.sup.2 is a substituted amino group, a substituted heterocyclic ring or a substituted alkyl. These compounds are oxytocin and vasopressin antagonists useful in the treatment of preterm labor, dysmenorrhea and for the stoppage of labor preparatory to cesarean delivery, timing of parturition, uterine hyperactivity, endometriosis, hypertension, congestive heart failure, hyponatremia and cognitive disorders. Also disclosed are pharmaceutical compositions containing these compounds, methods of their use and methods of their preparation.

REFERENCES:
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patent: 3654287 (1972-04-01), Dykstra et al.
patent: 3666764 (1972-05-01), Campbell et al.
patent: 4379933 (1983-04-01), Ong et al.
J. Parm. Sci (1982) 71, 3 pp. 291-294, by Crooks, et al.
J. Org. Chem. (1971) 36, 5, pp. 650-654, by Matier, et al.
J. Org. Chem. (1976) 41, 15, pp. 2528-2633, by Parkam, et al.
J. Chromatography (1977) 136, pp. 401-407, by Bryce, et al.

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