Amide forming chemical ligation

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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C548S240000

Reexamination Certificate

active

07667076

ABSTRACT:
An amide is formed by reacting an α-ketoacid or salt thereof in a decarboxylative condensation reaction with an amine or salt thereof comprising a nitrogen covalently bound to an atom selected from oxygen, nitrogen, and sulfur. The amide bond is formed between the α-carbon of the ketoacid and the nitrogen of the amine. The α-ketoacid can be formed using a novel sulfur reagent.

REFERENCES:
patent: 5103055 (1992-04-01), Cesa
patent: 0 635 488 (1995-01-01), None
Ahmad et al, Canadian Journal of Chemistry, vol. 30, 1340-1359, 1961.

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