Amide derivatives of Partricin A & Partricin B

Details Amide derivatives of Partricin A & Partricin B Amide derivatives of Partricin A & Partricin B

1990-11-14

1994-03-22

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544358, 546148, 424122, 536 65, 548400, 564191, C07D26530

Patent

active

052965970

ABSTRACT:
The present invention is directed towards a series of secondary and tertiary amide derivatives of Partricin A & Partricin B attached at the C-18 carboxyl group. The compounds can be used in the treatment of hypercholesteremia and hyperlipemia conditions, of steroidal imbalances, and as antifungal and antiprotozoan agents.

REFERENCES:
patent: 3961047 (1976-06-01), Bruzzese et al.
patent: 4783527 (1988-11-01), Falkowski et al.
Cyerwenski, A., et al, Journal of Antibiotics, vol. 40, #7, pp. 1023-1027 (1987).
Merck Index, 11th Ed, pp. 5733, 5734, 6997, 6998 (1989).
Tweit et al, J. of Antibiotics, vol. 35, pp. 997-1012 (1982).
Martindale The Extra Pharmacopoeia, 29th Ed, The Pharmaceutical Press, London, pp. 416-420 (1989).
Jarzebski et al, J. of Antibiotics, vol. 35, pp. 220-229 (1982).

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