Amide derivatives of p-isobutyl-phenyl-propionic acids and relat

Details Amide derivatives of p-isobutyl-phenyl-propionic acids and relat Amide derivatives of p-isobutyl-phenyl-propionic acids and relat

1981-07-15

1982-07-27

Breitenstein, G. T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424324, 562450, 564182, A61K 31195, C07C10122

Patent

active

043417981

ABSTRACT:
The amide derivatives of p-isobutyl-phenyl-propionic acid, having general formula ##STR1## wherein X is the radical of a substituted amine, of the group comprising lysine, metatrifluorotoluidine, glutamic acid and aspartic acid, show a good anti-inflammatory activity, accompanied by favourable side properties. For the preparation of the compounds of the invention, the p-isobutyl-phenyl-propionic acid is chlorinated, and the chlorinated derivative is reacted with the proper substituted amine.

REFERENCES:
patent: 3043868 (1962-07-01), Krimmel
patent: 3385886 (1968-05-01), Nicholson et al.
patent: 3407056 (1968-10-01), Schwartz

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