Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-09-18
1999-03-09
Kumar, Shailendra
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514464, 514465, 514469, 514524, 514563, 514617, 514618, 514619, 549377, 549378, 549441, 549467, 549468, 554 35, 554 36, 554 37, 558412, 558411, 558415, 564154, 564155, 564158, A61K 31335, A61K 31165, C07D31916, C07C23305
Patent
active
058801472
ABSTRACT:
Compounds of formula (I): ##STR1## wherein: R.sup.1 is alkyl; R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d are the same or different and each is hydrogen, optionally substituted alkyl, --(C.dbd.O)--B.sup.1 (wherein B.sup.1 is hydrogen or alkyl), nitro, --NR.sup.c R.sup.d (wherein R.sup.c is hydrogen or alkyl and Rd is alkyl), hydroxy, protected hydroxy group, alkoxy, cyano, alkylthio, alkylsulfinyl, alkylsulfonyl or halogen;
R.sup.3 is alkyl; R.sup.4 is a group of the formula (II) ##STR2## wherein A.sup.1 is a single bond, alkylene or alkenylene; R.sup.5a and R.sup.5b are the same or different and each is hydrogen, alkyl or --A.sup.4 R.sup.5.sub.c wherein A is a single bond, alkylene or alkenylene and R.sup.5.sub.c is alkoxy; and n is 0, and pharmaceutically acceptable salts thereof. Such compounds have valuable inhibitory activity against acyl-CoA (cholesterol acyl transferase).
REFERENCES:
patent: 4536346 (1985-08-01), Shepherd et al.
patent: 5534529 (1996-07-01), Yoshida et al.
patent: 5614550 (1997-03-01), Yoshida et al.
Chemical Abstracts, O'Brien et al., "Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase (ACAT) as Hypocholesterolemic Agents", vol. 121, No. 1, Jul. 4, 1994, Abstract No. 8837r.
Hayakawa Ichiro
Ishihara Sadao
Kasai Takashi
Kitazawa Eiichi
Koga Teiichiro
Kumar Shailendra
Sankyo Company Limited
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