Amide derivatives as NMDA receptor antagonists

Details Amide derivatives as NMDA receptor antagonists Amide derivatives as NMDA receptor antagonists

2008-05-20

2008-05-20

Chang, Celia (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S321000, C546S199000, C548S218000, C548S302100

Reexamination Certificate

active

11025287

ABSTRACT:
Compounds having NR2B selective NMDA receptor antagonist activity are disclosed of the formula (I)wheretwo of the neighboring R1, R2, R3and R4groups form an imidazole ring fused to the benzene ring of the indole nucleus, and the other two of R1, R2, R3and R4groups are hydrogen atoms,R5and R6together with the nitrogen between them form a saturated or unsaturated, 4-6 membered heterocyclic ring, which is substituted by phenoxy, phenyl-(C1-C4alkyl), phenyl-(C1-C4alkoxy), phenoxy-(C1-C4alkyl), or benzoyl, optionally substituted on the aromatic ring by one or more halogen atoms, cyano or hydroxy groups, C1-C4alkyl or C1-C4alkoxy groups,X is NH—,Y is a —CH— group,or pharmaceutically acceptable salts thereof formed with acids or bases.

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