Amide derivatives as NMDA receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S199000, C548S218000

Reexamination Certificate

active

07365083

ABSTRACT:
Compounds having NR2B selective NMDA receptor antagonist activity are disclosed of the formula (I)whereintwo of the neighboring R1, R2, R3and R4groups form an oxo-oxazolidine ring fused to the benzene ring of the indole nucleus,and the other two of R1, R2, R3and R4groups are hydrogen atoms,R5and R6together with the nitrogen between them form a saturated or unsaturated, 4-6 membered heterocyclic ring, which is substituted by phenoxy, phenyl-(C1-C4alkyl), phenyl-(C1-C4alkoxy), phenoxy-(C1-C4alkyl), or benzoyl, optionally substituted on the aromatic ring by one or more halogen atoms, cyano or hydroxy groups, C1-C4alkyl or C1-C4alkoxy groups,X is NH—,Y is a —CH— group,or pharmaceutically acceptable salts thereof formed with acids or bases.

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