Amide derivatives and methods of their use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S343000, C514S371000, C514S422000, C514S424000, C546S207000, C546S278400, C548S195000, C548S523000, C548S556000

Reexamination Certificate

active

10713746

ABSTRACT:
Amide derivatives of the general formulae Ia and Ib:are disclosed. Pharmaceutical compositions containing these compounds, and methods for their use, inter alia, for treating and/or preventing gastrointestinal disorders, pain, and pruritus are also disclosed.

REFERENCES:
patent: 4065573 (1977-12-01), Lednicer
patent: 4098904 (1978-07-01), Szmuszkovicz
patent: 4145435 (1979-03-01), Szmuszkovicz
patent: 4212878 (1980-07-01), Lednicer et al.
patent: 4359476 (1982-11-01), Kaplan et al.
patent: 4438130 (1984-03-01), Kaplan
patent: 4663343 (1987-05-01), Horwell et al.
patent: 4906655 (1990-03-01), Horwell et al.
patent: 5109135 (1992-04-01), D'Ambra et al.
patent: 5242944 (1993-09-01), Park et al.
patent: 5345943 (1994-09-01), Hargreaves et al.
patent: 5369131 (1994-11-01), Poli et al.
patent: 5434292 (1995-07-01), Saita et al.
patent: 5532266 (1996-07-01), Gottschlich et al.
patent: 5688955 (1997-11-01), Kruse et al.
patent: 5776972 (1998-07-01), Barber et al.
patent: 5804595 (1998-09-01), Portoghese et al.
patent: 6117438 (2000-09-01), Topolkaraev et al.
patent: 6423689 (2002-07-01), Booth et al.
patent: 6855706 (2005-02-01), Tanaka et al.
patent: 6992193 (2006-01-01), Le Bourdonnec et al.
patent: 11-180950 (1999-07-01), None
patent: 2002-173485 (2002-06-01), None
patent: WO 01/44179 (2001-06-01), None
Andreev, N., et al., “Opioids suppress spontaneous activity of polymodal nociceptors in rat paw skin induced by ultraviolet irradiation,”Neurosci., 1994, 58(4), 793-798.
Antonijevic, I.et al., “Perineurial defect and peripheral opioid analgesia in inflammation,”J. Neurosci., Jan. 1995, 15(1), 165-172.
Barber, A., et al., “Opioid agonists and antagonists: an evaluation of their peripheral actions in inflammation,”Med. Res. Rev., 1992, 12(5), 525-562.
Flynn, G.L., “Mechanism of percutaneous absorption from physicochemical evidence,” Percutaneous Absorption, Maibach, H.I., et al. (Eds.),Marcel Dekker Inc., 1985, 17-42.
Handwerker, et al., Pain and Inflammation, Proceeding of the VIthWorld Congress on Pain, Bond, et al. (Eds.),Elsevier Science Publishers BV, 1990, 59-70.
Hargreaves, K.M., et al., “The peripheral analgesic effects of opioids,”APS Journal, 1993, 2(1), 51-59.
Hassan, A.H.S., et al., “Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increase their density in the inflamed tissue,”Neuroscience, 1993, 55(1), 185-193.
Iyengar, S., et al., “Kappa opiate agonists modulate the hypothalamic-pituitary-adrenocortical axisin the rat,”J. Pharmacol. Exp. Ther., 1986, 238(2), 429-436.
Jain, K.K., “A guide to Drug Evaluation for chronic pain,”Emerging Drugs, 2000, 5(2), 241-257.
Leander, J.D., et al., “Diuresis and suppression of vasopressin by kappa opioids: comparison with Mu and Delta opioids and clonidine,”J. Pharm. Exp. Ther., 1985, 234, 463-469.
Lurz, R.A., et al., “Opioid reepors and eir parmaologial profiles,”J. of Recept. Res., 1992 12(3), 267-286.
Mansour, A., et al., “Anatomical distribution of opioid receptors in mammalians, an overview,”Opioid I, 1993, 79-105.
Manzanares, J., et al., “Kappa-opioid-receptor-mediated regulation of α-melanocyte-stimulating hormone secretion and tuberohypophysial dopaminergic neuronal activity,”Neuroendocrinology, 1990, 52, 200-205.
Millan, M.J., “κ-opioid receptors and analgesia,”Trends in Pharmacol. Sci., 1990, 11, 70-76.
Morley, J.E., et al., “Involvement of dynorphin and the kappa opioid receptor in feeding,”Peptides, 1983, 4, 797-800.
Neugebauer, V., et al., “N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists block the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat's knee joint,”J. Neurosci., Oct. 1993, 70(4), 1365-1377.
Pershing, L.K., et al., “In vivo pharmacokinetics and pharmacodynamics of topical ketoconazole and miconazole in human stratum corneum,”Antimicrob. Agents Chemother., Jan. 1994, 38(1), 90-95.
Przewlocki, R., et al., “Gene expression and localization of opioid peptides in immune cells of inflamed tissue: functional role in antinociception,”Neuroscience, 1992, 48(2), Pergamon Press Ltd., 491-500.
Ramabadran, K., et al., “A critical analysis of the experimental evaluation of nociceptive reactions in animals,”Pharm. Res., 1986, 3(5), 263-270.
Roy, S.D., et al., “Transdermal delivery of narcotic analgesics: pH, anatomical, and subject influences on cutaneous permeability of fentanyl and sufentanil,”Pharm. Res., 1990, 7(8), 842-847.
Sato, A., et al., “Changes in blood pressure and heart rate induced by movements of normal and inflamed knee joints,”Neurosci. Lett., 1984, 52, 55-60.
Schaible, H.-G., et al., “Effects of an experimental arthritis on the sensory properties of fine articular afferent units,”J. of Neurophysiol., 1985, 54(5), 1109-1122.
Schaible, H.-G.et al., “Afferent and spinal mechanisms of joint pain,”Pain, 1993, 55, 5-54.
Simon, E.J., “Opioid receptors and endogenous opioid peptides,”Med. Res. Rev., 1991, 11(4), 357-374.
Stein, C., et al., “Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of MU, Delta, and Kappa receptors,”J. Pharmacol. Exp. Ther., 1989,248(3), 1269-1275.
Stein, C., et al., “Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat,”Neurosci. Lett., 1988, 84, 225-228.
Stein, C., et al., “Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: alterations in behavior and nociceptive thresholds,”Pharmacol. Biochem.&Behav., 1988, 31, 445-451.
Taber, R.I., et al., “Agonist and antagonist interactions of opioids on acetic acid-induced abdominal stretching in mice,”J. or Pharmacol. Exp. Ther., 1969, 169(1), 29-38.
Tjølsen, A., et al., “The formalin test: an evaluation of the method,”Pain, 1992, 51, 5-17.
Wheeler-Aceto, H., et al., “Standardization of the rat paw formalin test for the evaluation of analgesics,”Psychopharmacology, 1991, 104, 35-44.
Williamson, J.W., et al, “Reflex increase in blood pressure induced by leg compression in man,”J. Physiol., 1994, 475.2, 351-357.
Wood, P.L., “Multiple opiate receptors: Support for unique Mu, Delta and Kappa sites,”Neuropharmacology, 1982, 21, 487-497.

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