Amide derivatives and antiallergic agents containing the same

Details Amide derivatives and antiallergic agents containing the same Amide derivatives and antiallergic agents containing the same

1986-12-08

1989-01-03

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546221, 544396, C07D21146, A61K 31445

Patent

active

047957522

ABSTRACT:
Novel amide derivatives are disclosed. As examples of said amide derivatives are mentioned 1-[2-[5-(3-methoxy-4-ethoxycarbonyloxyphenyl)-2,4-pentadienoyl]-aminoethyl ]-4-benzhydroxypiperidine, 1-[2-[3-(3-methoxy-4-ethoxycarbonyloxyphenyl)-2-propenoyl]aminoethyl]-4-be nzhydroxypiperidine, 1-[3-[5-(3-methoxy-4-ethoxycarbonyloxyphenyl)-2,4-pentadienoyl]aminopropyl ]-4-benzhydrylpiperazine and the like. These amide derivatives are useful as antiallergic agents.

REFERENCES:
patent: 3674843 (1972-07-01), Shen et al.
patent: 4673684 (1987-06-01), Wakabayashi et al.
Theodora W. Greene, Protective Groups in Organic Synthesis, publ. John Wiley & Sons (1981), pp. 104-105, 307-308.
T. Kametani et al, Journal of Heterocyclic Chemistry, vol. 12(2), Apr. 1975, pp. 259-262.
R. Hanselaer et al, Bull. Soc. Chim. Belg., vol. 92(11-12) (1983), pp. 1029-1037.
M. Flammang et al, Chemical Abstracts 71:49869v (1969).

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