Amide derivatives and antiallergic agents containing the same

Details Amide derivatives and antiallergic agents containing the same Amide derivatives and antiallergic agents containing the same

1988-08-31

1990-03-06

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544396, 514327, 546221, A61K 31495, A61K 31445, C07D29510, C07D21152

Patent

active

049066315

ABSTRACT:
Novel amide derivatives are disclosed. As examples of said amide derivatives are mentioned 1-[2-[5-(3-methoxy-4-ethoxycarbonyloxyphenyl)-2,4-pentadienoyl]-aminoethyl ]-4-benzhydroxypiperidine, 1-[2-[3-(3-methoxy-4-ethoxycarbonyloxyphenyl)-2-propenoyl]-4-benzhydroxypi peridine, 1-[3-[-(3-methoxy-4-ethoxycarbonyloxyphenyl)-2,4-pentadienoyl]aminopropyl] -4-benzhydrylpiperazine and the like. These amide derivatives are useful as antiallergic agents.

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Ueda et al., Chem. Abst. 101-230573x (1984), "Benzhydrylpiperazine Derivatives, and Their Pharmaceutical Composition".
Arai et al., CA 103-16527h (1985) "Anti-Allergic Action of S-Lipoxygenase Inhibitors".
Uno et al., CA 105-226063w (1986), "Cinnamamide Derivatives and Salts".
Uno et al., CA 106-176422k (1987), "Preparation of Pyridylacrylamidoalkyl Piperazines . . . ".
Takai et al., CA 107-154084v (1987), "Preparation of Benzenealkaneamides and . . . ".
Ooe et al., CA 109-190042e (1988), "Preparation of 3.5-di-tert-butyl-4-hydroxycinnamamide . . . ".

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