Amide derivatives and 5-lypoxygenase inhibitors containing the s

Details Amide derivatives and 5-lypoxygenase inhibitors containing the s Amide derivatives and 5-lypoxygenase inhibitors containing the s

1986-09-29

1989-03-28

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564170, A61K 31165

Patent

active

048164860

ABSTRACT:
Novel amide derivatives are disclosed. As examples of said amide derivatives are mentioned N-cyclohexyl-N-methyl-(2-(3-(3-methoxy-4-hydroxyphenyl)-2-(propenoylamino) -3, 5-dibromobenzyl)amine and N-cyclohexyl-N-methyl-(2-(5-(3-methoxy-4-hydroxyphenyl)-2,4-pentadienoylam ino )-3,5-dibromobenzyl)amine. These amide derivatives have a 5-lipoxygenase inhibitory activity and are useful as an antiallergic agent.

REFERENCES:
patent: 3192213 (1965-06-01), Krapcho
patent: 3268407 (1966-08-01), Hoffmann
patent: 4536346 (1985-08-01), Shepherd et al.
patent: 4562201 (1985-12-01), Stout et al.
patent: 4661505 (1987-04-01), Marshall et al.
Chemical Abstracts 99:5360W (1983).

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