Amide derivatives and 5-lipoxygenase inhibitors containing the s

Details Amide derivatives and 5-lipoxygenase inhibitors containing the s Amide derivatives and 5-lipoxygenase inhibitors containing the s

1985-04-02

1987-06-16

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514321, 514826, 546197, 546221, A61K 31445, C07D21146, C07D40512

Patent

active

046736840

ABSTRACT:
According to the invention, there are provided novel amide derivatives and 5-lipoxygenase inhibitors containing the same as an effective ingredient.
The above-mentioned compounds of the invention have been demonstrated to posses 5-lipoxygenase-inhibiting activities. These compounds can inhibit the production of leucotrienes such as LTC.sub.4 and LTD.sub.4 which are allergy-inducing factors by inhibiting the activity of 5-lipoxygenase. Accordingly, the amide derivatives can be used as 5-lipoxygenase inhibitors effective for allergic asthma, allergic rhinitis and the like.

REFERENCES:
patent: 2745837 (1956-05-01), Papa et al.
patent: 2751388 (1956-06-01), Levy
patent: 4261990 (1981-04-01), Bowman
patent: 4550116 (1985-10-01), Soto et al.

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