Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-06-03
1995-04-11
Chang, Celia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514256, 544333, 546 86, A61K 3144, C07D47106
Patent
active
054058520
ABSTRACT:
The present invention relates to certain novel amide ##STR1## derivatives which are pyrido[3,4-b]indol-2-ylacetamides which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these amide derivatives, processes for preparing the amide derivatives, pharmaceutical compositions containing such amide derivatives and methods for their use.
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patent: 4929736 (1990-05-01), Groutas
patent: 5232928 (1993-08-01), Skiles
patent: 5270301 (1993-12-01), Wolanin
Skiles, F. W. "Inhibition of Human Leukocyte Elastase (HLE) by N-Substituted Peptidyl Trifluoromethyl Ketones" J. Med. Chem. (1992), 35, 641-662.
Veale Chris A.
Warner Peter
Wolanin Donald J.
Browder Monte R.
Chang Celia
Harris Robert J.
Zeneca Limited
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