Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1983-07-13
1985-08-06
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514278, 514332, 514333, 514354, 514409, 514423, 546 16, 546226, 546207, 548408, 548525, 548527, 548526, 548537, A61K 3700, A01N 5700, A01N 4342, A01N 4336, C07D21500, C07D40100, C07D21106
Patent
active
045336563
ABSTRACT:
Amide derivatives of the formula: ##STR1## wherein either R.sup.1 is aryl or heterocyclic and A.sup.1 is a direct link, or R.sup.1 is aryl or heterocyclic, or hydrogen or amino and A.sup.1 is alkylene; X is --CH.sub.2 -- or --CO-- or has the formula ##STR2## wherein R.sup.11 and R.sup.12, which may be the same or different, each is alkyl, or R.sup.11 and R.sup.12 are joined to form alkylene; A.sup.2 is alkylene; R.sup.2 is hydrogen, aryl or alkyl which is unsubstituted or which bears an aryl substituent; R.sup.3 is hydrogen or alkyl which is unsubstituted or which bears a halogeno, hydroxy, amino, guanidino, carboxy, carbamoyl, mercapto, alkoxy, alkylamino, dialkylamino, cyclic amino, alkylthio, alkanoylamino, alkoxycarbonyl, arylalkoxycarbonyl, aryl or heterocyclyl substituent; R.sup.4 is alkyl which is unsubstituted or which bears an aryl substituent, or R.sup.4 is phenyl or alkylphenyl; n is 0 or 1; and either R.sup.5, R.sup.6, R.sup.15 and R.sup.16 are all hydrogen, or R.sup.5 and R.sup.6 are both hydrogen and R.sup.15 and R.sup.16 together form tetramethylene; or R.sup.5 and R.sup.6 together form a second bond between the two carbon atoms to which they are attached and R.sup.15 and R.sup.16 together form buta-1,3-dien-1,4-diyl; or a salt thereof; processes for their manufacture and pharmaceutical compositions containing them. The compounds are inhibitors of angiotensin converting enzyme.
REFERENCES:
patent: 4296110 (1981-10-01), Johnson
patent: 4303583 (1981-12-01), Kim et al.
patent: 4344949 (1982-08-01), Hoefle et al.
patent: 4374829 (1983-02-01), Harris et al.
Imperial Chemical Industries plc
Phillips Delbert R.
LandOfFree
Amide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Amide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amide derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-512814