Amide derivatives

Details Amide derivatives Amide derivatives

1982-03-01

1985-01-29

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514238, 514241, 514252, 514255, 514256, 514275, 514318, 514326, 514332, 514335, 514340, 514341, 514342, 514343, 544113, 544122, 544120, 544131, 544194, 544211, 544212, 544205, 544206, 544207, 544359, 544360, 544322, 544328, 544336, 544405, 546192, 546208, C07D23924, A61K 31505

Patent

active

044965648

ABSTRACT:
The invention relates to amide derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of the formula I: ##STR1## in which R.sup.1 is a hydrogen or 1-10C alkyl, 3-8C cycloalkyl, 4-14C cycloalkylalkyl, 3-6C alkenyl, 3-6C alkynyl, 1-6C alkanoyl, 6-10C aryl, 7-11C aralkyl or 7-11C aroyl, the aryl, aralkyl and aroyl radical being optionally substituted; ring X is a heterocyclic ring as defined in the specification; A is phenylene or 5-7C cycloalkylene, or a 1-8C alkylene into which is optionally inserted one or two groups; D is O or S; and R.sup.2 and R.sup.3 are hydrogen or a variety of radicals described in the specification: and the pharmaceutically-acceptable acid-addition salts thereof. Manufacturing processes and pharmaceutical compositions are also described.

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patent: 4252819 (1981-02-01), Hirata et al.
patent: 4262126 (1981-04-01), Gilman et al.
patent: 4309435 (1982-06-01), Yellin et al.
patent: 4315009 (1982-02-01), Jones et al.
patent: 4332949 (1982-06-01), Yellin et al.
patent: 4342765 (1982-08-01), Jones et al.
patent: 4362736 (1982-12-01), Hirata et al.

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