Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1982-03-01
1985-01-29
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514238, 514241, 514252, 514255, 514256, 514275, 514318, 514326, 514332, 514335, 514340, 514341, 514342, 514343, 544113, 544122, 544120, 544131, 544194, 544211, 544212, 544205, 544206, 544207, 544359, 544360, 544322, 544328, 544336, 544405, 546192, 546208, C07D23924, A61K 31505
Patent
active
044965648
ABSTRACT:
The invention relates to amide derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of the formula I: ##STR1## in which R.sup.1 is a hydrogen or 1-10C alkyl, 3-8C cycloalkyl, 4-14C cycloalkylalkyl, 3-6C alkenyl, 3-6C alkynyl, 1-6C alkanoyl, 6-10C aryl, 7-11C aralkyl or 7-11C aroyl, the aryl, aralkyl and aroyl radical being optionally substituted; ring X is a heterocyclic ring as defined in the specification; A is phenylene or 5-7C cycloalkylene, or a 1-8C alkylene into which is optionally inserted one or two groups; D is O or S; and R.sup.2 and R.sup.3 are hydrogen or a variety of radicals described in the specification: and the pharmaceutically-acceptable acid-addition salts thereof. Manufacturing processes and pharmaceutical compositions are also described.
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Gilman David J.
Yellin Tobias O.
ICI Americas Inc.
Imperial Chemical Industries plc
Rizzo Nicholas S.
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