Amide compounds, their production and use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514183, 514212, 514218, 5142388, 514317, 514330, 514331, 514365, 514374, 514385, 514399, 514423, 514427, 514428, 514613, 514615, 514616, 514617, 540450, 540607, 540609, 540610, 544162, 544168, 544170, 544390, A61K 31495, A61K 31445, A61K 31535, C07D29510

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049905112

ABSTRACT:
Amide compounds having glutamate receptor-inhibiting activity and having the formula: ##STR1## (wherein R.sub.1 and R.sub.2 each is hydrogen atom, an alkyl group or an acyl group, or ##STR2## is a cyclic amino group, m is an integer of 1 to 3, n is an integer of 0 to 4, x is an integer of 2 to 6 and y is an integer of 0 to 3) or salts thereof, are provided. The compounds are useful as a medicine for therapy or/and prevention of sequelae of cerebral apoplexy in warm-blooded animals.

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Simon et al., CA 108-111956j (1988).
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Yuichi Hashimoto et al., "Synthesis of Spider Toxin (JSTX-3) and its Analogs", Tetrahedron Letters, vol. 28, No. 30, pp. 3511-3514, 1987.
S. A. Minasyan et al., "Phenolic Acid Derivatives", Chemical Abstracts, vol. 106, No. 5, Feb. 2, 1987.

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