Amide compounds, process for preparing the same, and composition

Details Amide compounds, process for preparing the same, and composition Amide compounds, process for preparing the same, and composition

1988-09-02

1991-01-08

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514321, 514331, 514422, 514428, 514452, 514618, 514621, 564179, 564162, 564163, 564168, 564166, 546197, 546234, 548526, 548578, 549405, C07C23373, C07C23378, A61K 31165

Patent

active

049836331

ABSTRACT:
Amide-compounds represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino which can be substituted by lower alkyl, nitro, cyano, sulfamoyl which can be substituted by lower alkyl, R.sub.2 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino, nitro, wherein R.sub.1 and R.sub.2 can be combined to form methylenedioxy, R.sub.3 means hydrogen, lower alkyl, halogen, or amino, R.sub.4 and R.sub.5 may be the same or different and each represents lower alkyl or wherein R.sub.4 and R.sub.5 may be combined together with nitrogen to form 1-pyrrolidinyl or piperidino, and pharmacologically-acceptable acid-addition salts thereof, which exhibit excellent effects in the activation of gastric motor function, a process for preparation pharmaceutical compositons thereof, as well as a method for the treatment of a subject suffering from an ailment associated with inadequate gastric motor function by administrating such a compound to the said subject, are all disclosed.

REFERENCES:
patent: 3219528 (1965-11-01), Thominet
CA. Abstr 17500 (a-e) vol. 64, 1966 of Neth Appl. 6,505,819.

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