Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-08-23
2005-08-23
Huang, Evelyn Mei (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S303000, C514S337000, C514S349000, C546S113000, C546S119000, C546S280100, C546S279700, C546S282700, C546S309000
Reexamination Certificate
active
06933305
ABSTRACT:
The present invention relates to an amide compound of the formulawherein R1is a hydrogen and the like, R2is a hydrogen and the like, X is SO2and the like, Y is the formula (III) and the like and a is 2, an isomer thereof or pharmaceutically acceptable salts thereof. The compound of the present invention shows a remarkable and selective Rho kinase inhibitory action, is free of problematic toxicity, shows fine oral absorption and drug kinetics (absorption, distribution, metabolism, excretion and the like of the drug), and shows superior properties (e.g., stability etc.) as a compound. Accordingly, it can be used as a therapeutic drug for various diseases in which Rho kinase is involved.
REFERENCES:
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Sasaki et al. Pharmacology & Therapeutics. 2002, 93:225-232.
Loge et al. Journal of Enzyme Inhibition and Medicinal Chemistry, 2002, 17(6): 381-290.
H. Nagumo et al., “Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells”, Am. J. Physiol. Cell. Physiol., vol. 278, No. 1, Jan. 2000, C57-65.
Katayama Koshiro
Naito Yoichiro
Takanashi Shinichi
Tanaka Hiroshi
Uehata Masayoshi
Huang Evelyn Mei
Mitsubishi Pharma Corporation
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