Amide compounds and use of the same

Details Amide compounds and use of the same Amide compounds and use of the same

2006-05-02

2006-05-02

Raymond, Richard L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S331000, C514S364000, C514S395000, C514S539000, C514S542000, C514S563000, C544S400000, C546S234000, C548S131000, C548S221000, C560S039000, C560S040000, C562S444000, C562S445000

Reissue Patent

active

RE039088

ABSTRACT:
An amide compound of the formula (I): wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R1, R2, R3and R4are H, hydroxy and the like, R5is H, alkyl and the like, m is an integer of 0-6, R6is an optionally substituted aryl and the like, and R7is H, an optionally substituted alkyl and the like, a pharmaceutically acceptable acid addition salt thereof and a pharmaceutical containing same as an active ingredient. The amide compounds exhibit superior suppressive effects on cytokines directly or indirectly involved in inflammations, such as IL-8, IL-1, IL-6, TNF-α, GM-CSF and the like, and are useful for the prophylaxis and treatment of rheumatic diseases, arthritis due to gout and the like.

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