Amide compounds and medications containing the same

Details Amide compounds and medications containing the same Amide compounds and medications containing the same

2008-07-01

2008-07-01

Morris, Patricia L (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S270100

Reexamination Certificate

active

07393866

ABSTRACT:
The present invention provides to a novel compound having an ACAT inhibiting activity.The present invention relates to compounds represented by formula (I)wherein represents an optionally substituted divalent residue such as benzene, pyridine, cyclohexane or naphthalene, or a group,Het represents a 5- to 8-membered, substituted or unsubstituted heterocyclic group containing at least one heteroatom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, such as a monocyclic group, a polycyclic group or a group of a fused ring,X represents —NH—, an oxygen atom or a sulfur atom,Y represents —NR4—, an oxygen atom, a sulfur atom, a sulfoxide or a sulfone,Z represents a single bond or —NR5—,R4represents a hydrogen atom, a lower alkyl group, an aryl group or an optionally substituted silyl lower alkyl group,R5represents a hydrogen atom, a lower alkyl group, an aryl group or an optionally substituted silyl lower alkyl group, andn is an integer of from 1 to 15,or salts or solvates thereof, and a pharmaceutical composition containing at least one of these compounds.

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