Amide compounds

Details Amide compounds Amide compounds

1988-10-27

1990-03-27

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514535, 514563, 514616, 514533, 558414, 558416, 560 45, 560251, 562455, 564153, 564158, A61K 3124, A61K 31275, C07C10324, C07C12152

Patent

active

049121359

ABSTRACT:
Novel amide compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, acetyl, or propionyl; R.sup.2 is hydrogen or chlorine; R.sup.3 is hydrogen or a group of the formula: --CO.sub.2 R.sup.6 (wherein R.sup.6 is hydrogen, lower alkyl or alkali metal); R.sup.4 is hydrogen, trifluoromethyl, cyano, aminocarbonyl, or a group of the formula: --CO.sub.2 R.sup.7 (wherein R.sup.7 is hydrogen, lower alkyl, or alkali metal); R.sup.5 is hydrogen, or a group of the formula: --CO.sub.2 R.sup.8 (wherein R.sup.8 is hydrogen, lower alkyl, or alkali metal), which have excellent anti-allergic activity and are useful for the prophylaxis and treatment of various allergic diseases, and a pharmaceutical composition containing the amide compound as set forth above as an active ingredient.

REFERENCES:
patent: 3557211 (1971-01-01), Rumanowski
patent: 4248961 (1981-02-01), Hagen et al.
patent: 4250113 (1981-02-01), Nordal et al.
patent: 4568752 (1986-02-01), Fryberg

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